Khandesh, with its strong fort of Asirgarh, was incorporated into the Mughal empire by Akbar in:

Khandesh, in the Tapti valley of present-day Maharashtra and Madhya Pradesh, was incorporated into the Mughal empire by Akbar in 1601, after the capture of the powerful fort of Asirgarh.

About Khandesh:

• It was ruled by the Faruqi dynasty (founded by Malik Raja Faruqi in the late 14th century), with its capital at Burhanpur.
• It lay on the route between north India and the Deccan, and was therefore of great strategic importance.
• The Faruqi rulers had earlier accepted Mughal overlordship.

The siege of Asirgarh:

• When the ruler of Khandesh, Bahadur Khan Faruqi, refused to submit, Akbar personally led the campaign.
• Asirgarh was one of the strongest forts in India, built on a high hill and well supplied.
• After a long siege, the fort surrendered in January 1601, reportedly after the defenders were bribed or suffered from disease.
• This was Akbar's last major conquest.
• Khandesh was made a Mughal suba, and was later renamed "Dandesh", after Prince Daniyal.

Akbar's Deccan policy:

• After conquering most of north India, Akbar turned towards the Deccan.
• He sent missions to the Deccan Sultanates asking them to accept Mughal authority.
• His forces attacked Ahmadnagar; part of Ahmadnagar (Berar) was ceded in 1596, and the city of Ahmadnagar was captured in 1600.
• The conquest of Khandesh, Berar and part of Ahmadnagar brought the Mughal frontier into the Deccan.

Later history:

• Burhanpur became an important Mughal city and military base for the Deccan campaigns.
• Shah Jahan's wife Mumtaz Mahal died at Burhanpur in 1631.

Why not the other options?

• ✗1572 was the year of the conquest of Gujarat.
• ✗1580 is not linked with Khandesh.
• ✗1595 is not linked with Khandesh.